3FRF

S. aureus DHFR complexed with NADPH and iclaprim

Summary for 3FRF

Entry DOI	10.2210/pdb3frf/pdb
Related	3FRA 3FRB 3FRD 3FRE
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine, ... (4 entities in total)
Functional Keywords	dhfr, oxidoreductase, nadp, one-carbon metabolism
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	19244.56
Authors	Oefner, C.,Dale-Glenn, E. (deposition date: 2009-01-08, release date: 2010-01-12, Last modification date: 2024-03-20)
Primary citation	Oefner, C.,Bandera, M.,Haldimann, A.,Laue, H.,Schulz, H.,Mukhija, S.,Parisi, S.,Weiss, L.,Lociuro, S.,Dale, G.E. Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity J.Antimicrob.Chemother., 63:687-698, 2009 Cited by PubMed: 19211577 DOI: 10.1093/jac/dkp024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation