3FRF

S. aureus DHFR complexed with NADPH and iclaprim

3FRF の概要

• エントリーDOI: 10.2210/pdb3frf/pdb
• 関連するPDBエントリー: 3FRA 3FRB 3FRD 3FRE
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine, ... (4 entities in total)
• 機能のキーワード: dhfr, oxidoreductase, nadp, one-carbon metabolism
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19244.56

構造登録者

Oefner, C.,Dale-Glenn, E. (登録日: 2009-01-08, 公開日: 2010-01-12, 最終更新日: 2024-03-20)

• 主引用文献: Oefner, C.,Bandera, M.,Haldimann, A.,Laue, H.,Schulz, H.,Mukhija, S.,Parisi, S.,Weiss, L.,Lociuro, S.,Dale, G.E.; Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity; J.Antimicrob.Chemother., 63:687-698, 2009; PubMed: 19211577; DOI: 10.1093/jac/dkp024

実験手法

X-RAY DIFFRACTION (2.2 Å)