3FRD

S. aureus DHFR complexed with NADPH and folate

Summary for 3FRD

Entry DOI	10.2210/pdb3frd/pdb
Related	3FRA 3FRB 3FRE 3FRF
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, DIHYDROFOLIC ACID, ... (4 entities in total)
Functional Keywords	s aureus dhfr, oxidoreductase, nadp, one-carbon metabolism
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	19333.57
Authors	Oefner, C.,Dale-Glenn, E. (deposition date: 2009-01-08, release date: 2010-01-12, Last modification date: 2024-03-20)
Primary citation	Oefner, C.,Bandera, M.,Haldimann, A.,Laue, H.,Schulz, H.,Mukhija, S.,Parisi, S.,Weiss, L.,Lociuro, S.,Dale, G.E. Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity J.Antimicrob.Chemother., 63:687-698, 2009 Cited by PubMed: 19211577 DOI: 10.1093/jac/dkp024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation