3FQS
Crystal structure of spleen tyrosine kinase complexed with R406
Summary for 3FQS
Entry DOI | 10.2210/pdb3fqs/pdb |
Related | 3FQE 3FQH |
Descriptor | Tyrosine-protein kinase SYK, 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (3 entities in total) |
Functional Keywords | syk, spleen typrosine kinase, kinase inhibitor, r406, r788, amino-pyrimidine, atp-binding, host-virus interaction, kinase, nucleotide-binding, phosphoprotein, sh2 domain, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34354.46 |
Authors | Kuglstatter, A.,Villasenor, A.G. (deposition date: 2009-01-07, release date: 2009-03-10, Last modification date: 2023-09-06) |
Primary citation | Villasenor, A.G.,Kondru, R.,Ho, H.,Wang, S.,Papp, E.,Shaw, D.,Barnett, J.W.,Browner, M.F.,Kuglstatter, A. Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes. Chem.Biol.Drug Des., 73:466-470, 2009 Cited by PubMed: 19220318DOI: 10.1111/j.1747-0285.2009.00785.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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