3FQS

Crystal structure of spleen tyrosine kinase complexed with R406

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tyrosine-protein kinase SYK	polymer	291	33884.0	1	UniProt (P43405) Pfam (PF07714) In PDB	Homo sapiens (Human)	Spleen tyrosine kinase
2	A	6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one	non-polymer		470.5	1	Chemie (585)
3		water	water		18.0	91	Chemie (HOH)

Sequence modifications

A: 356 - 635 (UniProt: P43405)

PDB	External Database	Details
Met 353	-	expression tag
Ala 354	-	expression tag
Leu 355	-	expression tag
Glu 636	-	expression tag
Gly 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag
His 642	-	expression tag
His 643	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33884.0
Non-Polymers*	Number of molecules	1
	Total formula weight	470.5
All*	Total formula weight	34354.5

*Water molecules are not included.