3FQ9
Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications
Summary for 3FQ9
Entry DOI | 10.2210/pdb3fq9/pdb |
Related | 4INS |
Descriptor | Insulin, ZINC ION, ... (4 entities in total) |
Functional Keywords | receptor-binding, insulin design, rational, therapeutic implication, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glucose metabolism, hormone, pharmaceutical, secreted |
Cellular location | Secreted: P01308 P01308 |
Total number of polymer chains | 4 |
Total formula weight | 11792.20 |
Authors | Zhao, M.,Wan, Z.L.,Whittaker, L.,Xu, B.,Phillips, N.,Katsoyannis, P.,Whittaker, J.,Weiss, M.A. (deposition date: 2009-01-07, release date: 2009-08-04, Last modification date: 2023-09-06) |
Primary citation | Zhao, M.,Wan, Z.L.,Whittaker, L.,Xu, B.,Phillips, N.B.,Katsoyannis, P.G.,Ismail-Beigi, F.,Whittaker, J.,Weiss, M.A. Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications. J.Biol.Chem., 284:32178-32187, 2009 Cited by PubMed: 19773552DOI: 10.1074/jbc.M109.028399 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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