3FQ9

Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications

3FQ9 の概要

• エントリーDOI: 10.2210/pdb3fq9/pdb
• 関連するPDBエントリー: 4INS
• 分子名称: Insulin, ZINC ION, ... (4 entities in total)
• 機能のキーワード: receptor-binding, insulin design, rational, therapeutic implication, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glucose metabolism, hormone, pharmaceutical, secreted
• 細胞内の位置: Secreted: P01308 P01308
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 11792.20

構造登録者

Zhao, M.,Wan, Z.L.,Whittaker, L.,Xu, B.,Phillips, N.,Katsoyannis, P.,Whittaker, J.,Weiss, M.A. (登録日: 2009-01-07, 公開日: 2009-08-04, 最終更新日: 2023-09-06)

• 主引用文献: Zhao, M.,Wan, Z.L.,Whittaker, L.,Xu, B.,Phillips, N.B.,Katsoyannis, P.G.,Ismail-Beigi, F.,Whittaker, J.,Weiss, M.A.; Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.; J.Biol.Chem., 284:32178-32187, 2009; PubMed: 19773552; DOI: 10.1074/jbc.M109.028399

実験手法

X-RAY DIFFRACTION (1.35 Å)