3FKZ

X-ray structure of the non covalent swapped form of the S16G/T17N/A19P/A20S/K31C/S32C mutant of bovine pancreatic ribonuclease

Summary for 3FKZ

Entry DOI	10.2210/pdb3fkz/pdb
Related	1A2W 1BSR 1H8X 1TQ9 3BCP 3FL0 3FL1 3FL3
Descriptor	Ribonuclease pancreatic (2 entities in total)
Functional Keywords	3d-domain swapping, bovine seminal ribonuclease, non-covalent dimer, antitumor activity, quaternary structure flexibility, protein mutations and evolution, endonuclease, glycation, glycoprotein, hydrolase, nuclease, secreted
Biological source	Bos taurus (Bovine)
Cellular location	Secreted: P61823
Total number of polymer chains	2
Total formula weight	27674.93
Authors	Merlino, A.,Russo Krauss, I.,Perillo, M.,Mattia, C.A.,Ercole, C.,Picone, D.,Vergara, A.,Sica, F. (deposition date: 2008-12-18, release date: 2009-03-24, Last modification date: 2023-11-01)
Primary citation	Merlino, A.,Russo Krauss, I.,Perillo, M.,Mattia, C.A.,Ercole, C.,Picone, D.,Vergara, A.,Sica, F. Toward an antitumor form of bovine pancreatic ribonuclease: The crystal structure of three noncovalent dimeric mutants Biopolymers, 91:1029-1037, 2009 Cited by PubMed: 19280639 DOI: 10.1002/bip.21183 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation