3FIQ
Odorant Binding Protein OBP1
Summary for 3FIQ
| Entry DOI | 10.2210/pdb3fiq/pdb |
| Descriptor | Odorant-binding protein 1F, 1,2-ETHANEDIOL (3 entities in total) |
| Functional Keywords | lipocalin, oderant-binding protein, transport protein |
| Biological source | Rattus norvegicus (rat) |
| Total number of polymer chains | 2 |
| Total formula weight | 36492.25 |
| Authors | White, S.A. (deposition date: 2008-12-12, release date: 2009-05-19, Last modification date: 2024-11-13) |
| Primary citation | White, S.A.,Briand, L.,Scott, D.J.,Borysik, A.J. Structure of rat odorant-binding protein OBP1 at 1.6 A resolution Acta Crystallogr.,Sect.D, 65:403-410, 2009 Cited by PubMed Abstract: The nasal mucosa is a specialist interfacial region sandwiched between the olfactory system and the gaseous chemical milieu. In mammals and insects, this region is rich in odorant-binding proteins that are thought to aid olfaction by assisting mass transfer of the many different organoleptic compounds that make up the olfactory landscape. However, in mammals at least, our grasp on the exact function of odorant-binding proteins is tentative and better insight into the role of these proteins is warranted, not least because of their apparent significance in the olfactory systems of insects. Here, the crystal structure of rat odorant-binding protein 1 is reported at 1.6 A resolution. This protein is one of the best-characterized mammalian odorant-binding proteins and only the third such protein structure to be solved at high resolution. The protein was crystallized in the holo form and contains an unidentifiable ligand that is probably an artefact from the Pichia pastoris expression system. Comparisons are made between this structure and a modelled OBP1 structure produced using the crystal structure of aphrodisin as a template. Comparisons are also made between OBP1 and the other two rat OBP subtypes, for which crystallographic data are unavailable. Interestingly, we also show that OBP1 is monomeric, which is in contrast to its previous assignment. PubMed: 19390145DOI: 10.1107/S090744490900420X PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.599 Å) |
Structure validation
Download full validation report
