3FCU

Structure of headpiece of integrin aIIBb3 in open conformation

3FCU の概要

• エントリーDOI: 10.2210/pdb3fcu/pdb
• 関連するPDBエントリー: 1TYE 2VDO 2VDP 2VDQ 2VDR 3FCS
• 分子名称: Integrin, alpha 2b, Integrin beta-3, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: crystal structure; platelet integrin alphaiibbeta3; fibrinogen binding; allostery; therapeutic antagonism, cell adhesion, integrin, membrane, receptor, transmembrane, disease mutation, glycoprotein, host-virus interaction, phosphoprotein, cell adhesion-immune system complex, cell adhesion-blood clotting complex, cell adhesion/blood clotting
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 307075.08

構造登録者

Zhu, J.,Luo, B.-H.,Xiao, T.,Zhang, C.,Nishida, N.,Springer, T.A. (登録日: 2008-11-22, 公開日: 2009-01-20, 最終更新日: 2023-09-06)

• 主引用文献: Zhu, J.,Luo, B.H.,Xiao, T.,Zhang, C.,Nishida, N.,Springer, T.A.; Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.; Mol.Cell, 32:849-861, 2008; PubMed: 19111664; DOI: 10.1016/j.molcel.2008.11.018

実験手法

X-RAY DIFFRACTION (2.9 Å)