3FCU

Structure of headpiece of integrin aIIBb3 in open conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007155	biological_process	cell adhesion
A	0008305	cellular_component	integrin complex
C	0007155	biological_process	cell adhesion
C	0008305	cellular_component	integrin complex
E	0007155	biological_process	cell adhesion
E	0008305	cellular_component	integrin complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU

Chain	Residue	Details
B	SER121
A	ASP305
A	ASP365
A	ASP367
A	ASP369
A	TYR371
A	ASP373
A	ASP426
A	ASP428
A	ASN430
A	TYR432
B	GLU220
A	ASP434
C	GLU243
C	ASP245
C	ASP247
C	THR250
C	GLU252
C	ASP297
C	ASN299
C	ASP301
C	ARG303
D	SER121
C	ASP305
C	ASP365
C	ASP367
C	ASP369
C	TYR371
C	ASP373
C	ASP426
C	ASP428
C	ASN430
C	TYR432
D	GLU220
C	ASP434
E	GLU243
E	ASP245
E	ASP247
E	THR250
E	GLU252
E	ASP297
E	ASN299
E	ASP301
E	ARG303
F	SER121
E	ASP305
E	ASP365
E	ASP367
E	ASP369
E	TYR371
E	ASP373
E	ASP426
E	ASP428
E	ASN430
E	TYR432
F	GLU220
E	ASP434
A	ASN299
A	ASP301
A	ARG303

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCU

Chain	Residue	Details
B	SER123
D	SER123
F	SER123

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: in ADMIDAS binding site => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU, ECO:0007744|PDB:3IJE

Chain	Residue	Details
B	ASP126
B	ASP127
D	ASP126
D	ASP127
F	ASP126
F	ASP127

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU

Chain	Residue	Details
B	ASP158
F	ASN215
F	ASP217
F	PRO219
B	ASN215
B	ASP217
B	PRO219
D	ASP158
D	ASN215
D	ASP217
D	PRO219
F	ASP158

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	BINDING: in LIMBS binding site => ECO:0007744|PDB:4G1M

Chain	Residue	Details
B	ASP251
D	ASP251
F	ASP251

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	BINDING: in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3IJE

Chain	Residue	Details
B	MET335
D	MET335
F	MET335

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE

Chain	Residue	Details
B	ASN99
D	ASN99
F	ASN99

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE

Chain	Residue	Details
B	ASN320
B	ASN371
D	ASN320
D	ASN371
F	ASN320
F	ASN371

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:3IJE

Chain	Residue	Details
B	ASN452
D	ASN452
F	ASN452

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