3FC6

hRXRalpha & mLXRalpha with an indole Pharmacophore, SB786875

Summary for 3FC6

Entry DOI	10.2210/pdb3fc6/pdb
Descriptor	Retinoic acid receptor RXR-alpha, Nr1h3 protein, RETINOIC ACID, ... (5 entities in total)
Functional Keywords	liver x receptor, nuclear hormone receptors, agonists, epoxycholesterol, dna-binding, host-virus interaction, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, ubl conjugation, zinc, zinc-finger
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P19793
Total number of polymer chains	4
Total formula weight	117308.05
Authors	Washburn, D.G.,Hoang, T.H.,Campobasso, N.,Smallwood, A.,Parks, D.J.,Webb, C.L.,Frank, K.,Nord, M.,Duraiswami, C.,Evans, C.,Jaye, M.,Thompson, S.K. (deposition date: 2008-11-21, release date: 2009-02-10, Last modification date: 2023-12-27)
Primary citation	Washburn, D.G.,Hoang, T.H.,Campobasso, N.,Smallwood, A.,Parks, D.J.,Webb, C.L.,Frank, K.A.,Nord, M.,Duraiswami, C.,Evans, C.,Jaye, M.,Thompson, S.K. Synthesis and SAR of potent LXR agonists containing an indole pharmacophore. Bioorg.Med.Chem.Lett., 19:1097-1100, 2009 Cited by PubMed Abstract: A novel series of 1H-indol-1-yl tertiary amine LXR agonists has been designed. Compounds from this series were potent agonists with good rat pharmacokinetic parameters. In addition, the crystal structure of an LXR agonist bound to LXRalpha will be disclosed. PubMed: 19167885 DOI: 10.1016/j.bmcl.2009.01.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.063 Å)

Structure validation