3F8J

Mouse UHRF1 SRA domain bound with hemi-methylated CpG, crystal structure in space group C222(1)

3F8J の概要

• エントリーDOI: 10.2210/pdb3f8j/pdb
• 関連するPDBエントリー: 2ZO0 2ZO1 2ZO2 3F8I
• 分子名称: E3 ubiquitin-protein ligase UHRF1, 5'-D(*DCP*DCP*DAP*DTP*DGP*(5CM)P*DGP*DCP*DTP*DGP*DAP*DC)-3', 5'-D(*DGP*DTP*DCP*DAP*DGP*DCP*DGP*DCP*DAP*DTP*DGP*DG)-3', ... (5 entities in total)
• 機能のキーワード: uhrf1, sra, base flipping, 5-methylcytosine, cpg methylation, cell cycle, developmental protein, dna damage, dna repair, dna-binding, ligase, metal-binding, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation pathway, zinc-finger, ligase-dna complex, ligase/dna
• 由来する生物種: Mus musculus (house mouse); 詳細
• 細胞内の位置: Nucleus: Q8VDF2
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 32028.31

構造登録者

Hashimoto, H.,Horton, J.R.,Zhang, X.,Cheng, X. (登録日: 2008-11-12, 公開日: 2009-01-06, 最終更新日: 2023-09-06)

• 主引用文献: Hashimoto, H.,Horton, J.R.,Zhang, X.,Cheng, X.; UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications.; Epigenetics, 4:8-14, 2009; PubMed: 19077538

実験手法

X-RAY DIFFRACTION (1.99 Å)