3F8G
The X-ray structure of a dimeric variant of human pancreatic ribonuclease with high cytotoxic and antitumor activities
Summary for 3F8G
Entry DOI | 10.2210/pdb3f8g/pdb |
Related | 1BSR 1E21 1R3M 2K11 |
Descriptor | Ribonuclease pancreatic, SULFATE ION (3 entities in total) |
Functional Keywords | antitumor agent, ribonuclease, 3d domain swapping, unswapped dimer, dimers, endonuclease, glycoprotein, hydrolase, nuclease, secreted |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P07998 |
Total number of polymer chains | 2 |
Total formula weight | 28708.46 |
Authors | Merlino, A.,Avella, G.,Mazzarella, L.,Sica, F. (deposition date: 2008-11-12, release date: 2009-02-10, Last modification date: 2023-09-06) |
Primary citation | Merlino, A.,Avella, G.,Di Gaetano, S.,Arciello, A.,Piccoli, R.,Mazzarella, L.,Sica, F. Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant. Protein Sci., 18:50-57, 2009 Cited by PubMed: 19177350DOI: 10.1002/pro.6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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