3F6U

Crystal structure of human Activated Protein C (APC) complexed with PPACK

3F6U の概要

• エントリーDOI: 10.2210/pdb3f6u/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000020
• 分子名称: Vitamin K-dependent protein C heavy chain, Vitamin K-dependent protein C light chain, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (6 entities in total)
• 機能のキーワード: blood coagulation, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38285.32

構造登録者

Schmidt, A.E.,Padmanabhan, K.,Underwood, M.C.,Bode, W.,Mather, T.,Bajaj, S.P. (登録日: 2008-11-06, 公開日: 2008-11-25, 最終更新日: 2024-03-13)

• 主引用文献: Schmidt, A.E.,Padmanabhan, K.,Underwood, M.C.,Bode, W.,Mather, T.,Bajaj, S.P.; Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC).; J.Biol.Chem., 277:28987-28995, 2002; PubMed: 12029084; DOI: 10.1074/jbc.M201892200

実験手法

X-RAY DIFFRACTION (2.8 Å)