3F6K

Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with neurotensin

3F6K の概要

• エントリーDOI: 10.2210/pdb3f6k/pdb
• 分子名称: Sortilin, Neurotensin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: protein sorting receptor, 10-bladed beta-propeller, cys-rich domains, ssortilin, sortilin vps10p-d, protein-peptide complex, developmental protein, differentiation, endocytosis, endoplasmic reticulum, endosome, glycoprotein, golgi apparatus, lysosome, membrane, phosphoprotein, receptor, transmembrane, transport, cytoplasmic vesicle, secreted, signaling protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 79703.86

構造登録者

Quistgaard, E.M.,Madsen, P.,Groftehauge, M.K.,Nissen, P.,Petersen, C.M.,Thirup, S. (登録日: 2008-11-06, 公開日: 2008-12-30, 最終更新日: 2024-11-06)

主引用文献

Quistgaard, E.M.,Madsen, P.,Groftehauge, M.K.,Nissen, P.,Petersen, C.M.,Thirup, S.S.
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain.
Nat.Struct.Mol.Biol., 16:96-98, 2009

PubMed Abstract: The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2-A resolution, revealing that the C-terminal part of neurotensin binds in the tunnel of a ten-bladed beta-propeller domain. Binding competition studies suggest that additional binding sites, for example, for the prodomain of nerve growth factor-beta, are present in the tunnel and that competition for binding relates to the restricted space inside the propeller.

PubMed: 19122660
DOI: 10.1038/nsmb.1543

実験手法

X-RAY DIFFRACTION (2 Å)