3F0U

Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-phenylphenyl)but-1-ynyl]-6-methylpyrimidine

3F0U の概要

• エントリーDOI: 10.2210/pdb3f0u/pdb
• 関連するPDBエントリー: 3F0B 3F0Q 3F0S 3F0V 3F0X
• 分子名称: Trimethoprim-sensitive dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, ... (4 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Staphylococcus aureus RF122
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19135.41

構造登録者

Anderson, A.C.,Frey, K.M.,Liu, J.,Lombardo, M.N. (登録日: 2008-10-26, 公開日: 2009-03-24, 最終更新日: 2024-04-03)

• 主引用文献: Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Wright, D.L.,Anderson, A.C.; Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance.; J.Mol.Biol., 387:1298-1308, 2009; PubMed: 19249312; DOI: 10.1016/j.jmb.2009.02.045

実験手法

X-RAY DIFFRACTION (1.6 Å)