3F0S

Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-(3,5-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine

3F0S の概要

• エントリーDOI: 10.2210/pdb3f0s/pdb
• 関連するPDBエントリー: 3F0B 3F0Q 3F0U 3F0V 3F0X
• 分子名称: Trimethoprim-sensitive dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (3 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Staphylococcus aureus RF122
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19147.47

構造登録者

Anderson, A.C.,Frey, K.M.,Liu, J.,Lombardo, M.N. (登録日: 2008-10-25, 公開日: 2009-10-06, 最終更新日: 2024-04-03)

• 主引用文献: Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Smith, A.E.,Priestley, N.D.,Wright, D.L.,Anderson, A.C.; Crystallographic Complexes of Wildtype and Mutant MRSA DHFR Reveal Interactions for Lead Design; To be Published,

実験手法

X-RAY DIFFRACTION (2.7 Å)