3EWX

K314A mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, degraded to BMP

3EWX の概要

• エントリーDOI: 10.2210/pdb3ewx/pdb
• 関連するPDBエントリー: 3EWU 3EWW 3EWY 3EWZ 3EX0 3EX1 3EX2 3EX3 3EX4 3EX5 3EX6
• 分子名称: Orotidine-5'-phosphate decarboxylase, 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: decarboxylase, tim barrel, unusual catalysis, disease mutation, glycosyltransferase, lyase, multifunctional enzyme, pyrimidine biosynthesis, transferase
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28750.03

構造登録者

Heinrich, D.,Wittmann, J.,Diederichsen, U.,Rudolph, M. (登録日: 2008-10-16, 公開日: 2009-04-07, 最終更新日: 2023-12-27)

• 主引用文献: Heinrich, D.,Diederichsen, U.,Rudolph, M.G.; Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase; Chemistry, 15:6619-6625, 2009; PubMed: 19472232; DOI: 10.1002/chem.200900397

実験手法

X-RAY DIFFRACTION (1.4 Å)