3EQF

X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with K252A and MG2P

3EQF の概要

• エントリーDOI: 10.2210/pdb3eqf/pdb
• 関連するPDBエントリー: 3EQC 3EQD 3EQG 3EQH 3EQI
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, K-252A, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: mek1 kinase, atp-binding, disease mutation, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40668.06

構造登録者

Fischmann, T.O. (登録日: 2008-09-30, 公開日: 2009-02-24, 最終更新日: 2024-02-21)

• 主引用文献: Fischmann, T.O.,Smith, C.K.,Mayhood, T.W.,Myers, J.E.,Reichert, P.,Mannarino, A.,Carr, D.,Zhu, H.,Wong, J.,Yang, R.S.,Le, H.V.,Madison, V.S.; Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.; Biochemistry, 48:2661-2674, 2009; PubMed: 19161339; DOI: 10.1021/bi801898e

実験手法

X-RAY DIFFRACTION (2.7 Å)