3EQC

X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with compound 1, ATP-GS AND MG2P

Summary for 3EQC

Entry DOI	10.2210/pdb3eqc/pdb
Related	3EQD 3EQF 3EQG 3EQH 3EQI
Descriptor	Dual specificity mitogen-activated protein kinase kinase 1, 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... (7 entities in total)
Functional Keywords	mek1 kinase, atp-binding, disease mutation, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	41222.48
Authors	Fischmann, T.O. (deposition date: 2008-09-30, release date: 2009-02-24, Last modification date: 2024-02-21)
Primary citation	Fischmann, T.O.,Smith, C.K.,Mayhood, T.W.,Myers, J.E.,Reichert, P.,Mannarino, A.,Carr, D.,Zhu, H.,Wong, J.,Yang, R.S.,Le, H.V.,Madison, V.S. Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48:2661-2674, 2009 Cited by PubMed: 19161339 DOI: 10.1021/bi801898e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation