3EQ6

Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in a ternary complex with products

Summary for 3EQ6

Entry DOI	10.2210/pdb3eq6/pdb
Related	3B7W 3C5E 3DAY
Descriptor	Acyl-coenzyme A synthetase ACSM2A, ADENOSINE MONOPHOSPHATE, Butyryl Coenzyme A, ... (4 entities in total)
Functional Keywords	middle-chain acyl-coa synthetase, xenobiotic/medium-chain fatty acid-coa ligase, atp-binding, fatty acid metabolism, lipid metabolism, magnesium, metal-binding, mitochondrion, nucleotide-binding polymorphism, transit peptide, ligase, structural genomics, sgc, structural genomics consortium
Biological source	Homo sapiens (Human)
Cellular location	Mitochondrion matrix : Q08AH3
Total number of polymer chains	2
Total formula weight	129038.81
Authors	Pilka, E.S.,Kochan, G.,Yue, W.W.,Bhatia, C.,Von delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2008-09-30, release date: 2008-10-28, Last modification date: 2023-11-01)
Primary citation	Kochan, G.,Pilka, E.S.,von Delft, F.,Oppermann, U.,Yue, W.W. Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A J.Mol.Biol., 388:997-1008, 2009 Cited by PubMed: 19345228 DOI: 10.1016/j.jmb.2009.03.064 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation