3EQ6
Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in a ternary complex with products
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Acyl-coenzyme A synthetase ACSM2A | polymer | 570 | 63334.6 | 2 | UniProt (Q08AH3) Pfam (PF00501) Pfam (PF13193) | Homo sapiens (Human) | Acyl-CoA synthetase medium-chain family member 2A, Middle-chain acyl-CoA synthetase 2A, Butyryl coenzyme A synthetase 2A, Butyrate-CoA ligase 2A |
| 2 | C, E (A, B) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (34768) PubChem (83862) PubChem (40467049) PubChem (40469468) PubChem (446048) PubChem (44348067) PubChem (45358029) PubChem (40459109) PubChem (515384) PubChem (46874558) PubChem (638042) PubChem (46875232) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (5316444) PubChem (5742864) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (12163610) PubChem (12358355) PubChem (92144436) PubChem (122197642) PubChem (12358354) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 3 | D, F (A, B) | Butyryl Coenzyme A | non-polymer | 837.6 | 2 | Chemie (BCO) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 447 | Chemie (HOH) |
Sequence modifications
A, B: 32 - 577 (UniProt: Q08AH3)
| PDB | External Database | Details |
|---|---|---|
| Met 8 | - | expression tag |
| Gly 9 | - | expression tag |
| His 10 | - | expression tag |
| His 11 | - | expression tag |
| His 12 | - | expression tag |
| His 13 | - | expression tag |
| His 14 | - | expression tag |
| His 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Ser 17 | - | expression tag |
| Gly 18 | - | expression tag |
| Val 19 | - | expression tag |
| Asp 20 | - | expression tag |
| Leu 21 | - | expression tag |
| Gly 22 | - | expression tag |
| Thr 23 | - | expression tag |
| Glu 24 | - | expression tag |
| Asn 25 | - | expression tag |
| Leu 26 | - | expression tag |
| Tyr 27 | - | expression tag |
| Phe 28 | - | expression tag |
| Gln 29 | - | expression tag |
| Ser 30 | - | expression tag |
| Met 31 | - | expression tag |
| Pro 64 | Leu 64 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 126669.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2369.7 | |
| All* | Total formula weight | 129038.8 |
