3EP6

Human AdoMetDC D174N mutant complexed with S-Adenosylmethionine methyl ester and no putrescine bound

3EP6 の概要

• エントリーDOI: 10.2210/pdb3ep6/pdb
• 関連するPDBエントリー: 1I72 1I79 1I7B 1I7C 1I7M 1JEN 3EP3 3EP4 3EP5 3EP7 3EP8 3EP9 3EPA 3EPB
• 分子名称: S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, PYRUVIC ACID, ... (5 entities in total)
• 機能のキーワード: adometdc with mutation in putrescine binding site, decarboxylase, lyase, pyruvate, s-adenosyl-l-methionine, spermidine biosynthesis, zymogen
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38084.35

構造登録者

Bale, S.,Lopez, M.M.,Makhatadze, G.I.,Fang, Q.,Pegg, A.E.,Ealick, S.E. (登録日: 2008-09-29, 公開日: 2008-12-23, 最終更新日: 2023-11-15)

• 主引用文献: Bale, S.,Lopez, M.M.,Makhatadze, G.I.,Fang, Q.,Pegg, A.E.,Ealick, S.E.; Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase.; Biochemistry, 47:13404-13417, 2008; PubMed: 19053272; DOI: 10.1021/bi801732m

実験手法

X-RAY DIFFRACTION (1.7 Å)