3EOU

tRNA-guanine transglycosylase in complex with 6-amino-4-(2-hydroxyethyl)-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

Summary for 3EOU

• Entry DOI: 10.2210/pdb3eou/pdb
• Related: 3C2N 3EOS
• Descriptor: Queuine tRNA-ribosyltransferase, ZINC ION, 6-amino-4-(2-hydroxyethyl)-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, ... (5 entities in total)
• Functional Keywords: tim barrel, glycosyltransferase, metal-binding, queuosine biosynthesis, transferase, trna processing
• Biological source: Zymomonas mobilis
• Total number of polymer chains: 1
• Total formula weight: 43449.58

Authors

Ritschel, T.,Heine, A.,Klebe, G. (deposition date: 2008-09-29, release date: 2009-09-15, Last modification date: 2024-03-20)

• Primary citation: Ritschel, T.,Kohler, P.C.,Neudert, G.,Heine, A.,Diederich, F.,Klebe, G.; How to Replace the Residual Solvation Shell of Polar Active Site Residues to Achieve Nanomolar Inhibition of tRNA-Guanine Transglycosylase; Chemmedchem, 4:2012-2023, 2009; PubMed: 19894214; DOI: 10.1002/cmdc.200900343

Experimental method

X-RAY DIFFRACTION (1.93 Å)