3EOB
Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form II
Summary for 3EOB
Entry DOI | 10.2210/pdb3eob/pdb |
Related | 3EO9 3EOA |
Descriptor | Efalizumab Fab fragment, light chain, Efalizumab Fab fragment, heavy chain, Integrin alpha-L, ... (4 entities in total) |
Functional Keywords | efalizumab, fab, antibody, lfa-1, cd11a, i domain, alternative splicing, calcium, cell adhesion, glycoprotein, integrin, magnesium, membrane, polymorphism, receptor, transmembrane, immune system-cell adhesion complex, immune system/cell adhesion |
Biological source | Homo sapiens More |
Cellular location | Membrane; Single-pass type I membrane protein: P20701 |
Total number of polymer chains | 6 |
Total formula weight | 135863.55 |
Authors | |
Primary citation | Li, S.,Wang, H.,Peng, B.,Zhang, M.,Zhang, D.,Hou, S.,Guo, Y.,Ding, J. Efalizumab binding to the LFA-1 alphaL I domain blocks ICAM-1 binding via steric hindrance. Proc.Natl.Acad.Sci.USA, 106:4349-4354, 2009 Cited by PubMed: 19258452DOI: 10.1073/pnas.0810844106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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