3EOB

Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form II

Summary for 3EOB

• Entry DOI: 10.2210/pdb3eob/pdb
• Related: 3EO9 3EOA
• Descriptor: Efalizumab Fab fragment, light chain, Efalizumab Fab fragment, heavy chain, Integrin alpha-L, ... (4 entities in total)
• Functional Keywords: efalizumab, fab, antibody, lfa-1, cd11a, i domain, alternative splicing, calcium, cell adhesion, glycoprotein, integrin, magnesium, membrane, polymorphism, receptor, transmembrane, immune system-cell adhesion complex, immune system/cell adhesion
• Biological source: Homo sapiens; More
• Cellular location: Membrane; Single-pass type I membrane protein: P20701
• Total number of polymer chains: 6
• Total formula weight: 135863.55

Authors

Li, S.,Ding, J. (deposition date: 2008-09-26, release date: 2009-04-14, Last modification date: 2011-07-13)

• Primary citation: Li, S.,Wang, H.,Peng, B.,Zhang, M.,Zhang, D.,Hou, S.,Guo, Y.,Ding, J.; Efalizumab binding to the LFA-1 alphaL I domain blocks ICAM-1 binding via steric hindrance.; Proc.Natl.Acad.Sci.USA, 106:4349-4354, 2009; PubMed: 19258452; DOI: 10.1073/pnas.0810844106

Experimental method

X-RAY DIFFRACTION (3.6 Å)