3EGX

Crystal structure of the mammalian COPII-coat protein Sec23a/24a complexed with the SNARE protein Sec22b and bound to the transport signal sequence of the SNARE protein Bet1

Summary for 3EGX

Entry DOI	10.2210/pdb3egx/pdb
Related	3EFO 3EG9 3EGD 3EH1
Descriptor	Protein transport protein Sec23A, Protein transport protein Sec24A, Vesicle-trafficking protein SEC22b, ... (5 entities in total)
Functional Keywords	copii coat protein, vesicle transport, transport signal sequence, disease mutation, endoplasmic reticulum, er-golgi transport, golgi apparatus, membrane, protein transport, transport, phosphoprotein, transmembrane
Biological source	Homo sapiens (Human) More
Cellular location	Smooth endoplasmic reticulum membrane; Peripheral membrane protein: Q15436 Cytoplasm (By similarity): O95486 Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity): O75396
Total number of polymer chains	4
Total formula weight	189678.68
Authors	Goldberg, J.,Mancias, J.D. (deposition date: 2008-09-11, release date: 2008-10-21, Last modification date: 2024-02-21)
Primary citation	Mancias, J.D.,Goldberg, J. Structural basis of cargo membrane protein discrimination by the human COPII coat machinery. Embo J., 27:2918-2928, 2008 Cited by PubMed: 18843296 DOI: 10.1038/emboj.2008.208 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation