3EG1

Crystal structure of the N114Q mutant of ABL-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions

Summary for 3EG1

Entry DOI	10.2210/pdb3eg1/pdb
Related	1BBZ 2O88 3EG0 3EG2 3EG3
Descriptor	Proto-oncogene tyrosine-protein kinase ABL1, p41 peptide, SULFATE ION, ... (4 entities in total)
Functional Keywords	beta, sh3 domain, atp-binding, cell adhesion, cytoskeleton, kinase, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase, signaling protein, transferase-signaling protein complex, transferase/signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
Total number of polymer chains	4
Total formula weight	16309.86
Authors	Camara-Artigas, A. (deposition date: 2008-09-10, release date: 2009-09-15, Last modification date: 2023-08-30)
Primary citation	Palencia, A.,Camara-Artigas, A.,Pisabarro, M.T.,Martinez, J.C.,Luque, I. Role of interfacial water molecules in proline-rich ligand recognition by the Src homology 3 domain of Abl. J.Biol.Chem., 285:2823-2833, 2010 Cited by PubMed: 19906645 DOI: 10.1074/jbc.M109.048033 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation