3EG1
Crystal structure of the N114Q mutant of ABL-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase ABL1 | polymer | 63 | 7023.7 | 2 | UniProt (P00519) Pfam (PF00018) | Homo sapiens (human) | p150, c- ABL, Abelson murine leukemia viral oncogene homolog 1 |
| 2 | C, D (C, D) | p41 peptide | polymer | 11 | 1035.1 | 2 | synthetic construct | ||
| 3 | E, F (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
A, B: 60 - 121 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Met 59 | - | initiating methionine |
| Gln 114 | Asn 114 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 16117.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 192.1 | |
| All* | Total formula weight | 16309.9 |
