3EG1

Crystal structure of the N114Q mutant of ABL-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions

Summary for 3EG1

Related2O88 1BBZ 3EG0 3EG2 3EG3
DescriptorProto-oncogene tyrosine-protein kinase ABL1, p41 peptide, SULFATE ION, ... (4 entities in total)
Functional Keywordsbeta, sh3 domain, atp-binding, cell adhesion, cytoskeleton, kinase, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase, signaling protein, transferase-signaling protein complex, transferase/signaling protein
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor P00519
Total number of polymer chains4
Total molecular weight16309.86
Authors
Camara-Artigas, A. (deposition date: 2008-09-10, release date: 2009-09-15, Last modification date: 2011-07-13)
Primary citation
Palencia, A.,Camara-Artigas, A.,Pisabarro, M.T.,Martinez, J.C.,Luque, I.
Role of interfacial water molecules in proline-rich ligand recognition by the Src homology 3 domain of Abl.
J.Biol.Chem., 285:2823-2833, 2010
PubMed: 19906645 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M109.048033
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.253701.8%3.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution