3EFQ

T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-714

Summary for 3EFQ

Entry DOI	10.2210/pdb3efq/pdb
Descriptor	Farnesyl pyrophosphate synthase, MAGNESIUM ION, 1-(2,2-diphosphonoethyl)-3-(octyloxy)pyridinium, ... (4 entities in total)
Functional Keywords	protein-bisphosphonate complex, isoprene biosynthesis, transferase
Biological source	Trypanosoma brucei
Total number of polymer chains	2
Total formula weight	89889.97
Authors	Cao, R.,Gao, Y.,Robinson, H.,Oldfield, E. (deposition date: 2008-09-09, release date: 2009-05-05, Last modification date: 2024-02-21)
Primary citation	Zhang, Y.,Cao, R.,Yin, F.,Hudock, M.P.,Guo, R.T.,Krysiak, K.,Mukherjee, S.,Gao, Y.G.,Robinson, H.,Song, Y.,No, J.H.,Bergan, K.,Leon, A.,Cass, L.,Goddard, A.,Chang, T.K.,Lin, F.Y.,Van Beek, E.,Papapoulos, S.,Wang, A.H.,Kubo, T.,Ochi, M.,Mukkamala, D.,Oldfield, E. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J.Am.Chem.Soc., 131:5153-5162, 2009 Cited by PubMed: 19309137 DOI: 10.1021/ja808285e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation