3EFQ
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-714
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| A | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| B | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A3002 |
| Chain | Residue |
| A | ASP103 |
| A | ASP107 |
| A | 7143001 |
| A | MG3004 |
| A | HOH3007 |
| A | HOH3131 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A3003 |
| Chain | Residue |
| A | HOH3059 |
| A | HOH3065 |
| A | HOH3135 |
| A | ASP255 |
| A | ASP259 |
| A | 7143001 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A3004 |
| Chain | Residue |
| A | ASP103 |
| A | ASP107 |
| A | 7143001 |
| A | MG3002 |
| A | HOH3019 |
| A | HOH3109 |
| A | HOH3112 |
| site_id | AC4 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE 714 A3001 |
| Chain | Residue |
| A | TYR99 |
| A | GLU102 |
| A | ASP103 |
| A | MET106 |
| A | ASP107 |
| A | ARG112 |
| A | GLN172 |
| A | LYS212 |
| A | THR213 |
| A | GLN252 |
| A | ASP255 |
| A | LYS269 |
| A | MG3002 |
| A | MG3003 |
| A | MG3004 |
| A | HOH3007 |
| A | HOH3011 |
| A | HOH3019 |
| A | HOH3065 |
| A | HOH3083 |
| A | HOH3112 |
| A | HOH3131 |
| A | HOH3135 |
| B | ILE130 |
| B | ASN131 |
| B | LEU134 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B4002 |
| Chain | Residue |
| B | ASP103 |
| B | ASP107 |
| B | 7144001 |
| B | MG4004 |
| B | HOH4006 |
| B | HOH4007 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B4003 |
| Chain | Residue |
| B | ASP255 |
| B | 7144001 |
| B | HOH4009 |
| B | HOH4023 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B4004 |
| Chain | Residue |
| B | ASP103 |
| B | ASP107 |
| B | 7144001 |
| B | MG4002 |
| B | HOH4029 |
| B | HOH4107 |
| B | HOH4124 |
| site_id | AC8 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 714 B4001 |
| Chain | Residue |
| A | ASN131 |
| A | LEU134 |
| B | HIS98 |
| B | TYR99 |
| B | GLU102 |
| B | ASP103 |
| B | MET106 |
| B | ASP107 |
| B | ARG112 |
| B | GLN172 |
| B | LYS212 |
| B | THR213 |
| B | ASP255 |
| B | LYS269 |
| B | MG4002 |
| B | MG4003 |
| B | MG4004 |
| B | HOH4007 |
| B | HOH4011 |
| B | HOH4023 |
| B | HOH4045 |
| B | HOH4124 |
Functional Information from PROSITE/UniProt
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| A | PHE251 | |
| A | ARG112 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| B | PHE251 | |
| B | ARG112 |
