3EDY

Crystal Structure of the Precursor Form of Human Tripeptidyl-Peptidase 1

Summary for 3EDY

Entry DOI	10.2210/pdb3edy/pdb
Descriptor	Tripeptidyl-peptidase 1, CALCIUM ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	protease, tpp1, sedolisin, batten disease, lincl, zymogen, prodomain, exopeptidase, endopeptidase, s53 family, cln2, catalytic triad, oxyanion hole, disease mutation, epilepsy, glycoprotein, hydrolase, lysosome, neuronal ceroid lipofuscinosis, serine protease
Biological source	Homo sapiens (human)
Cellular location	Lysosome : O14773
Total number of polymer chains	1
Total formula weight	60542.30
Authors	Guhaniyogi, J.,Sohar, I.,Das, K.,Lobel, P.,Stock, A.M. (deposition date: 2008-09-03, release date: 2008-11-18, Last modification date: 2020-07-29)
Primary citation	Guhaniyogi, J.,Sohar, I.,Das, K.,Stock, A.M.,Lobel, P. Crystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid Lipofuscinosis J.Biol.Chem., 284:3985-3997, 2009 Cited by PubMed: 19038967 DOI: 10.1074/jbc.M806943200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation