Crystal Structure of the Precursor Form of Human Tripeptidyl-Peptidase 1

Summary for 3EDY

DescriptorTripeptidyl-peptidase 1, CALCIUM ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywordsprotease, tpp1, sedolisin, batten disease, lincl, zymogen, prodomain, exopeptidase, endopeptidase, s53 family, cln2, catalytic triad, oxyanion hole, disease mutation, epilepsy, glycoprotein, hydrolase, lysosome, neuronal ceroid lipofuscinosis, serine protease
Biological sourceHomo sapiens (human)
Cellular locationLysosome  O14773
Total number of polymer chains1
Total molecular weight60542.3
Guhaniyogi, J.,Sohar, I.,Das, K.,Lobel, P.,Stock, A.M. (deposition date: 2008-09-03, release date: 2008-11-18, Last modification date: 2020-07-29)
Primary citation
Guhaniyogi, J.,Sohar, I.,Das, K.,Stock, A.M.,Lobel, P.
Crystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid Lipofuscinosis
J.Biol.Chem., 284:3985-3997, 2009
PubMed: 19038967 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M806943200
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21511 0.4% 2.8% 5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21