3EDY

Crystal Structure of the Precursor Form of Human Tripeptidyl-Peptidase 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004175	molecular_function	endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005764	cellular_component	lysosome
A	0005794	cellular_component	Golgi apparatus
A	0006508	biological_process	proteolysis
A	0006629	biological_process	lipid metabolic process
A	0007040	biological_process	lysosome organization
A	0007399	biological_process	nervous system development
A	0007417	biological_process	central nervous system development
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0008240	molecular_function	tripeptidyl-peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0030163	biological_process	protein catabolic process
A	0030855	biological_process	epithelial cell differentiation
A	0035727	molecular_function	lysophosphatidic acid binding
A	0042277	molecular_function	peptide binding
A	0042470	cellular_component	melanosome
A	0043171	biological_process	peptide catabolic process
A	0043202	cellular_component	lysosomal lumen
A	0045121	cellular_component	membrane raft
A	0045453	biological_process	bone resorption
A	0046872	molecular_function	metal ion binding
A	0050885	biological_process	neuromuscular process controlling balance
A	0055037	cellular_component	recycling endosome
A	0070062	cellular_component	extracellular exosome
A	0070198	biological_process	protein localization to chromosome, telomeric region
A	0120146	molecular_function	sulfatide binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	175
Details	Propeptide: {"description":"Removed in mature form","featureId":"PRO_0000027374","evidences":[{"source":"PubMed","id":"11054422","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	364
Details	Domain: {"description":"Peptidase S53"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"19038966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19038967","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"19038966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19038967","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11054422","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19038966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19038967","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19038966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19038967","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19038966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19038967","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19038966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19038967","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1nlu