3ECR

Structure of human porphobilinogen deaminase

Summary for 3ECR

DescriptorPorphobilinogen deaminase, 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid (3 entities in total)
Functional Keywordshuman porphobilinogen deaminase, heme biosynthesis, porphobilinogen hinge, alternative splicing, cytoplasm, disease mutation, porphyrin biosynthesis, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm (Probable) P08397
Total number of polymer chains2
Total molecular weight80151.37
Authors
Song, G.,Li, Y.,Cheng, C.,Zhao, Y.,Gao, A.,Zhang, R.,Joachimiak, A.,Shaw, N.,Liu, Z.J. (deposition date: 2008-09-01, release date: 2008-09-30, Last modification date: 2011-07-13)
Primary citation
Song, G.,Li, Y.,Cheng, C.,Zhao, Y.,Gao, A.,Zhang, R.,Joachimiak, A.,Shaw, N.,Liu, Z.J.
Structural insight into acute intermittent porphyria.
Faseb J., 23:396-404, 2009
PubMed: 18936296 (PDB entries with the same primary citation)
DOI: 10.1096/fj.08-115469
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.182 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.266130.5%3.6%7.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3ecr
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Molmil generated image of 3ecr
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Molmil generated image of 3ecr
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More Biological unit images

Molmil generated image of 3ecr
no rotation
Molmil generated image of 3ecr
rotated about x axis by 90°
Molmil generated image of 3ecr
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3ecr.pdb1.gz [53.04 KB])
Coordinate files for Biological unit (3ecr.pdb2.gz [51.69 KB])