3ECN

Crystal structure of PDE8A catalytic domain in complex with IBMX

Summary for 3ECN

• Entry DOI: 10.2210/pdb3ecn/pdb
• Related: 3ECM
• Descriptor: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, 3-ISOBUTYL-1-METHYLXANTHINE, ZINC ION, ... (5 entities in total)
• Functional Keywords: ibmx, pde8a catalytic domain, refolding, alternative splicing, camp, hydrolase, magnesium, manganese, metal-binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 78803.96

Authors

Wang, H.,Yan, Z.,Yang, S.,Cai, J.,Robinson, H.,Ke, H. (deposition date: 2008-09-01, release date: 2008-11-25, Last modification date: 2024-04-03)

• Primary citation: Wang, H.,Yan, Z.,Yang, S.,Cai, J.,Robinson, H.,Ke, H.; Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity; Biochemistry, 47:12760-12768, 2008; PubMed: 18983167; DOI: 10.1021/bi801487x

Experimental method

X-RAY DIFFRACTION (2.1 Å)