3ECN
Crystal structure of PDE8A catalytic domain in complex with IBMX
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE IBM A 3 |
| Chain | Residue |
| A | MET670 |
| A | ILE744 |
| A | TYR748 |
| A | PHE767 |
| A | GLN778 |
| A | PHE781 |
| A | PHE785 |
| A | HOH884 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE IBM B 3 |
| Chain | Residue |
| B | MET670 |
| B | ILE744 |
| B | TYR748 |
| B | GLN778 |
| B | PHE781 |
| B | PHE785 |
| B | HOH126 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 1 |
| Chain | Residue |
| A | HIS560 |
| A | HIS596 |
| A | ASP597 |
| A | ASP726 |
| A | HOH820 |
| A | HOH821 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 2 |
| Chain | Residue |
| A | ASP597 |
| A | HOH820 |
| A | HOH822 |
| A | HOH823 |
| A | HOH824 |
| A | HOH825 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 1 |
| Chain | Residue |
| B | HOH11 |
| B | HOH12 |
| B | HIS560 |
| B | HIS596 |
| B | ASP597 |
| B | ASP726 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 2 |
| Chain | Residue |
| B | HOH11 |
| B | HOH13 |
| B | HOH14 |
| B | HOH15 |
| B | HOH16 |
| B | ASP597 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGrtNsF |
| Chain | Residue | Details |
| A | HIS596-PHE607 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18983167","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ECM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ECN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
