3ECN
Crystal structure of PDE8A catalytic domain in complex with IBMX
Summary for 3ECN
Entry DOI | 10.2210/pdb3ecn/pdb |
Related | 3ECM |
Descriptor | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, 3-ISOBUTYL-1-METHYLXANTHINE, ZINC ION, ... (5 entities in total) |
Functional Keywords | ibmx, pde8a catalytic domain, refolding, alternative splicing, camp, hydrolase, magnesium, manganese, metal-binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 78803.96 |
Authors | |
Primary citation | Wang, H.,Yan, Z.,Yang, S.,Cai, J.,Robinson, H.,Ke, H. Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity Biochemistry, 47:12760-12768, 2008 Cited by PubMed: 18983167DOI: 10.1021/bi801487x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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