3ECM

Crystal structure of the unliganded PDE8A catalytic domain

Summary for 3ECM

• Entry DOI: 10.2210/pdb3ecm/pdb
• Related: 3ECN
• Descriptor: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, ZINC ION, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: phosphodiesterase 8a pde8a inhibitor selectivity, alternative splicing, camp, hydrolase, magnesium, manganese, metal-binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 39179.73

Authors

Wang, H.,Yan, Z.,Yang, S.,Cai, J.,Robinson, H.,Ke, H. (deposition date: 2008-09-01, release date: 2008-11-25, Last modification date: 2024-04-03)

• Primary citation: Wang, H.,Yan, Z.,Yang, S.,Cai, J.,Robinson, H.,Ke, H.; Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity; Biochemistry, 47:12760-12768, 2008; PubMed: 18983167; DOI: 10.1021/bi801487x

Experimental method

X-RAY DIFFRACTION (1.9 Å)