3E8R
Crystal structure of catalytic domain of TACE with hydroxamate inhibitor
3E8R の概要
エントリーDOI | 10.2210/pdb3e8r/pdb |
関連するPDBエントリー | 2ddf 2fv5 2fv9 |
関連するBIRD辞書のPRD_ID | PRD_000919 |
分子名称 | ADAM 17, ZINC ION, (1R,2S)-N~2~-hydroxy-1-{4-[(2-phenylquinolin-4-yl)methoxy]benzyl}cyclopropane-1,2-dicarboxamide, ... (6 entities in total) |
機能のキーワード | tace adam17 zn-endopeptidase, cleavage on pair of basic residues, glycoprotein, hydrolase, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, protease, sh3-binding, transmembrane, zymogen |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Membrane; Single-pass type I membrane protein: P78536 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 63010.03 |
構造登録者 | |
主引用文献 | Mazzola, R.D.,Zhu, Z.,Sinning, L.,McKittrick, B.,Lavey, B.,Spitler, J.,Kozlowski, J.,Neng-Yang, S.,Zhou, G.,Guo, Z.,Orth, P.,Madison, V.,Sun, J.,Lundell, D.,Niu, X. Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket. Bioorg.Med.Chem.Lett., 18:5809-5814, 2008 Cited by PubMed: 18835710DOI: 10.1016/j.bmcl.2008.09.045 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.9 Å) |
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