3E8L

The Crystal Structure of the Double-headed Arrowhead Protease Inhibitor A in Complex with Two Trypsins

Summary for 3E8L

Entry DOI	10.2210/pdb3e8l/pdb
Descriptor	Serine proteinase inhibitor A, Cationic trypsin, GLYCEROL, ... (10 entities in total)
Functional Keywords	beta-trefoil fold, protease inhibitor, trypsin, complex, digestion, hydrolase, metal-binding, protease, secreted, serine protease, zymogen, hydrolase inhibitor-hydrolase complex, hydrolase inhibitor/hydrolase
Biological source	Sagittaria sagittifolia (Arrowhead) More
Cellular location	Secreted, extracellular space: P00760
Total number of polymer chains	3
Total formula weight	68656.12
Authors	Bao, R.,Jiang, C.-H.,Chi, C.W.,Lin, S.X.,Chen, Y.X. (deposition date: 2008-08-20, release date: 2009-07-28, Last modification date: 2023-11-01)
Primary citation	Bao, R.,Zhou, C.Z.,Jiang, C.-H.,Lin, S.X.,Chi, C.W.,Chen, Y.X. The ternary structure of double-headed arrowhead protease inhibitor API-A complexed with two trypsins reveals a novel reactive site conformation. J.Biol.Chem., 284:26676-26684, 2009 Cited by PubMed: 19640842 DOI: 10.1074/jbc.M109.022095 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation