Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004175 | molecular_function | endopeptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0007586 | biological_process | digestion |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0097180 | cellular_component | serine protease inhibitor complex |
| A | 0097655 | molecular_function | serpin family protein binding |
| B | 0004175 | molecular_function | endopeptidase activity |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006508 | biological_process | proteolysis |
| B | 0007586 | biological_process | digestion |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0097180 | cellular_component | serine protease inhibitor complex |
| B | 0097655 | molecular_function | serpin family protein binding |
| C | 0004866 | molecular_function | endopeptidase inhibitor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 178 |
| Chain | Residue |
| C | GLN12 |
| C | LEU21 |
| C | TYR22 |
| C | LYS175 |
| C | PHE176 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 179 |
| Chain | Residue |
| C | TYR134 |
| C | PRO2 |
| C | VAL4 |
| C | LEU73 |
| C | THR131 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL C 180 |
| Chain | Residue |
| A | TYR37 |
| C | HOH218 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT C 181 |
| Chain | Residue |
| A | GOL2 |
| A | VAL73 |
| C | SER64 |
| C | ALA65 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT C 182 |
| Chain | Residue |
| A | SER110 |
| C | LEU13 |
| C | LEU15 |
| C | GLY16 |
| C | ASN18 |
| C | PRO20 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 183 |
| Chain | Residue |
| B | GLY143 |
| C | LYS78 |
| C | TRP122 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA A 1 |
| Chain | Residue |
| A | THR122 |
| A | SER123 |
| A | LYS201 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 3 |
| Chain | Residue |
| A | GLN170 |
| A | SER210 |
| A | HOH250 |
| A | HOH289 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 5 |
| Chain | Residue |
| A | HIS38 |
| A | CYS40 |
| A | GLY190 |
| A | HOH253 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA A 7 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA A 8 |
| Chain | Residue |
| A | GLY60 |
| A | LYS215 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA A 10 |
| site_id | BC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 2 |
| Chain | Residue |
| A | ASN94 |
| A | THR95 |
| A | LEU96 |
| A | GLN170 |
| A | TRP208 |
| A | HOH268 |
| A | HOH299 |
| C | PHE143 |
| C | ACT181 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 239 |
| Chain | Residue |
| A | SER35 |
| A | TYR37 |
| A | PHE39 |
| A | LYS58 |
| A | HOH297 |
| C | PRO149 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 12 |
| Chain | Residue |
| A | GLN130 |
| A | CYS131 |
| A | VAL197 |
| A | CYS198 |
| A | SER199 |
| A | GLY200 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 240 |
| Chain | Residue |
| A | SER81 |
| A | LYS106 |
| A | GLN214 |
| A | LYS215 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 6 |
| Chain | Residue |
| A | NA7 |
| A | TYR37 |
| A | HIS38 |
| A | HOH315 |
| C | ARG126 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA B 6 |
| Chain | Residue |
| B | LYS140 |
| B | SER142 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA B 11 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 1 |
| Chain | Residue |
| B | ASN94 |
| B | THR95 |
| B | GLN170 |
| B | TRP208 |
| C | PRO84 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 3 |
| Chain | Residue |
| B | GLN189 |
| B | GLY211 |
| B | CYS212 |
| B | HOH271 |
| C | THR91 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 239 |
| Chain | Residue |
| B | SER85 |
| B | ILE86 |
| B | VAL87 |
| site_id | CC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 7 |
| Chain | Residue |
| B | EDO8 |
| B | CYS124 |
| B | ALA125 |
| B | ASP160 |
| B | GLN203 |
| B | LYS223 |
| B | CYS225 |
| B | HOH279 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 8 |
| Chain | Residue |
| B | MET175 |
| B | LYS223 |
| B | EDO7 |
| B | ASP160 |
| B | THR172 |
| B | SER173 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 240 |
| Chain | Residue |
| B | ASN97 |
| B | ASN98 |
| B | SER173 |
| B | ASN174 |
| site_id | CC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT B 2 |
| Chain | Residue |
| B | HIS55 |
| C | TYR114 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC |
| Chain | Residue | Details |
| A | VAL51-CYS56 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV |
| Chain | Residue | Details |
| A | ASP186-VAL197 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | LYS58 | |
| A | LEU102 | |
| A | PRO195 | |
| B | LYS58 | |
| B | LEU102 | |
| B | PRO195 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ILE70 | |
| B | GLY75 | |
| B | ILE80 | |
| B | GLN189 | |
| B | SER192 | |
| B | PRO195 | |
| A | VAL72 | |
| A | GLY75 | |
| A | ILE80 | |
| A | GLN189 | |
| A | SER192 | |
| A | PRO195 | |
| B | ILE70 | |
| B | VAL72 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER192 | |
| A | ASP99 | |
| A | HIS55 | |
| site_id | CSA10 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER192 | |
| B | ASP99 | |
| B | HIS55 | |
| B | GLY190 | |
| site_id | CSA11 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER192 | |
| A | GLY193 | |
| A | ASP99 | |
| A | HIS55 | |
| site_id | CSA12 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER192 | |
| B | GLY193 | |
| B | ASP99 | |
| B | HIS55 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER192 | |
| B | ASP99 | |
| B | HIS55 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP99 | |
| A | HIS55 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP99 | |
| B | HIS55 | |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER192 | |
| A | GLY190 | |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER192 | |
| B | GLY190 | |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER192 | |
| A | GLY193 | |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER192 | |
| B | GLY193 | |
| site_id | CSA9 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER192 | |
| A | ASP99 | |
| A | HIS55 | |
| A | GLY190 | |
