3E8C

Crystal structures of the kinase domain of PKA in complex with ATP-competitive inhibitors

3E8C の概要

• エントリーDOI: 10.2210/pdb3e8c/pdb
• 関連するPDBエントリー: 3E87 3E88 3E8D 3E8E
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor peptide, 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-6-{[(2R)-2-amino-3-phenylpropyl]oxy}-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol, ... (4 entities in total)
• 機能のキーワード: pka, akt2, kinase, pki, bovine, inhibitor, atp-binding, camp, lipoprotein, myristate, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, protein kinase inhibitor
• 由来する生物種: Bos taurus (cow); 詳細
• 細胞内の位置: Cytoplasm : P00517
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 260845.93

構造登録者

Concha, N.O.,Elkins, P.A.,Smallwood, A.,Ward, P. (登録日: 2008-08-19, 公開日: 2008-11-18, 最終更新日: 2017-10-25)

• 主引用文献: Rouse, M.B.,Seefeld, M.A.,Leber, J.D.,McNulty, K.C.,Sun, L.,Miller, W.H.,Zhang, S.,Minthorn, E.A.,Concha, N.O.,Choudhry, A.E.,Schaber, M.D.,Heerding, D.A.; Aminofurazans as potent inhibitors of AKT kinase; Bioorg.Med.Chem.Lett., 19:1508-1511, 2009; PubMed: 19179070; DOI: 10.1016/j.bmcl.2009.01.002

実験手法

X-RAY DIFFRACTION (2.2 Å)