3E5A

Crystal structure of Aurora A in complex with VX-680 and TPX2

Summary for 3E5A

Entry DOI	10.2210/pdb3e5a/pdb
Descriptor	Serine/threonine-protein kinase 6, Targeting protein for Xklp2, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, ... (5 entities in total)
Functional Keywords	aurora a, serine/threonine-protein kinase, cofactor, tpx2, vx-680, inhibitor, phosphorylation, atp-binding, cell cycle, nucleotide-binding, phosphoprotein, transferase, nucleus
Biological source	Homo sapiens More
Cellular location	Cytoplasm, cytoskeleton, centrosome: O14965 Nucleus: Q9ULW0
Total number of polymer chains	2
Total formula weight	36718.54
Authors	Zhao, B.,Smallwood, A.,Lai, Z. (deposition date: 2008-08-13, release date: 2008-10-28, Last modification date: 2023-08-30)
Primary citation	Zhao, B.,Smallwood, A.,Yang, J.,Koretke, K.,Nurse, K.,Calamari, A.,Kirkpatrick, R.B.,Lai, Z. Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2. Protein Sci., 17:1791-1797, 2008 Cited by PubMed: 18662907 DOI: 10.1110/ps.036590.108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation