3E5A
Crystal structure of Aurora A in complex with VX-680 and TPX2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase 6 | polymer | 268 | 31173.7 | 1 | UniProt (O14965) Pfam (PF00069) | Homo sapiens | Aurora kinase A, Aurora-A, Serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase |
| 2 | B (B) | Targeting protein for Xklp2 | polymer | 44 | 4984.2 | 1 | UniProt (Q9ULW0) Pfam (PF09041) | Homo sapiens | TPX2, Restricted expression proliferation-associated protein 100, p100, Differentially expressed in cancerous and non-cancerous lung cells 2, DIL-2, Protein fls353, Hepatocellular carcinoma-associated antigen 519 |
| 3 | C (A) | CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE | non-polymer | 464.6 | 1 | Chemie (VX6) | |||
| 4 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 58 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36157.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 560.6 | |
| All* | Total formula weight | 36718.5 |
