3E37

Protein farnesyltransferase complexed with bisubstrate ethylenediamine scaffold inhibitor 5

3E37 の概要

• エントリーDOI: 10.2210/pdb3e37/pdb
• 関連するPDBエントリー: 1D8D 1KZO 1KZP 1SA4 1SA5 2IEJ 3E30 3E32 3E33 3E34
• 関連するBIRD辞書のPRD_ID: PRD_900003
• 分子名称: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: ftase, farnesyltransferase, protein farnesyltransferase, malaria, plasmodium, falciparum, ethylenediamine, prenyltransferase, transferase, metal-binding, phosphoprotein, zinc
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 94296.33

構造登録者

Hast, M.A.,Beese, L.S. (登録日: 2008-08-06, 公開日: 2009-03-10, 最終更新日: 2024-02-21)

• 主引用文献: Hast, M.A.,Fletcher, S.,Cummings, C.G.,Pusateri, E.E.,Blaskovich, M.A.,Rivas, K.,Gelb, M.H.,Van Voorhis, W.C.,Sebti, S.M.,Hamilton, A.D.,Beese, L.S.; Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.; Chem.Biol., 16:181-192, 2009; PubMed: 19246009; DOI: 10.1016/j.chembiol.2009.01.014

実験手法

X-RAY DIFFRACTION (1.8 Å)