3E37
Protein farnesyltransferase complexed with bisubstrate ethylenediamine scaffold inhibitor 5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | polymer | 379 | 44459.4 | 1 | UniProt (P49354) Pfam (PF01239) | Homo sapiens (Human) | CAAX farnesyltransferase subunit alpha, Ras proteins prenyltransferase alpha, FTase-alpha, Type I protein geranyl-geranyltransferase subunit alpha, GGTase-I-alpha |
| 2 | B (B) | Protein farnesyltransferase subunit beta | polymer | 437 | 48822.4 | 1 | UniProt (P49356) Pfam (PF00432) | Homo sapiens (Human) | FTase-beta, CAAX farnesyltransferase subunit beta, RAS proteins prenyltransferase beta |
| 3 | C (C) | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900003) | sucrose | ||
| 4 | D (B) | tert-butyl 4-({(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)[(2-methylphenyl)sulfonyl]amino}methyl)piperidine-1-carboxylate | non-polymer | 606.8 | 1 | Chemie (ED5) | |||
| 5 | E (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 729 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 93281.8 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 342.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 672.2 | |
| All* | Total formula weight | 94296.3 |
