3DZJ

Crystal structure of human CD38 extracellular domain E226Q mutant, NMN complex

Summary for 3DZJ

Related3DZF 3DZG 3DZH 3DZI 3DZK
DescriptorADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE (3 entities in total)
Functional Keywordsnmn complex, e226q mutant, beta sheets, alpha bundle, alternative splicing, diabetes mellitus, glycoprotein, hydrolase, membrane, nad, polymorphism, receptor, signal-anchor, transmembrane
Biological sourceHomo sapiens
Cellular locationMembrane; Single-pass type II membrane protein P28907
Total number of polymer chains2
Total molecular weight61341.25
Authors
Liu, Q.,Kriksunov, I.A.,Jiang, H.,Graeff, R.,Lin, H.,Lee, H.C.,Hao, Q. (deposition date: 2008-07-29, release date: 2008-11-04, Last modification date: 2011-07-13)
Primary citation
Liu, Q.,Kriksunov, I.A.,Jiang, H.,Graeff, R.,Lin, H.,Lee, H.C.,Hao, Q.
Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15:1068-1078, 2008
PubMed: 18940667 (PDB entries with the same primary citation)
DOI: 10.1016/j.chembiol.2008.08.007
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.28271.8%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report