3DY7
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
Summary for 3DY7
Entry DOI | 10.2210/pdb3dy7/pdb |
Related | 1S9I 1S9J |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | dual specificity protein kinase, non-atp-competitive kinase inhibitor, inhibitor-bound protein kinase, atp-bound protein kinase, acetylation, atp-binding, disease mutation, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 38914.26 |
Authors | Ohren, J.F.,Pavlovsky, A.,Zhang, E. (deposition date: 2008-07-25, release date: 2009-06-16, Last modification date: 2023-08-30) |
Primary citation | Tecle, H.,Shao, J.,Li, Y.,Kothe, M.,Kazmirski, S.,Penzotti, J.,Ding, Y.H.,Ohren, J.,Moshinsky, D.,Coli, R.,Jhawar, N.,Bora, E.,Jacques-O'Hagan, S.,Wu, J. Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg.Med.Chem.Lett., 19:226-229, 2009 Cited by PubMed: 19019675DOI: 10.1016/j.bmcl.2008.10.108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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